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Qianghu Wang | Baoli Hu | Xin Hu | Hoon Kim | Massimo Squatrito | Lisa Scarpace | Ana C. Their “personal regulome” analysis framework reveals chromatin features that may be predictive of clinical response to epigenetic therapy. Cancer immunotherapies can be classified into agents that amplify natural immune responses (e.g., checkpoint inhibitors) versus synthetic immunotherapies designed to initiate new responses (e.g., monoclonal antibodies [m Abs], chimeric antigen receptors [CARs]).

de Carvalho | Sali Lyu | Pengping Li | Yan Li | Floris Barthel | Hee Jin Cho | Yu-Hsi Lin | Nikunj Satani | Emmanuel Martinez-Ledesma | Siyuan Zheng | Edward Chang | Charles-Etienne Gabriel Sauvé | Adriana Olar | Zheng D. Small-molecule chemical probes or tools have become progressively more important in recent years as valuable reagents to investigate fundamental biological mechanisms and processes causing disease, including cancer. Checkpoint inhibitors mediate unprecedented benefit in some adult cancers, but have not demonstrated significant activity in pediatric cancers, likely due their paucity of neoantigens.

Gulfem Dilek Guler | Charles Albert Tindell | Robert Pitti | Catherine Wilson | Katrina Nichols | Tommy Kai Wai Cheung | Hyo-Jin Kim | Matthew Wongchenko | Yibing Yan | Benjamin Haley | Trinna Cuellar | Joshua Webster | Navneet Alag | Ganapati Hegde | Erica Jackson | Tracy Leah Nance | Paul Garrett Giresi | Kuan-Bei Chen | Jinfeng Liu | Suchit Jhunjhunwala | Jeff Settleman | Jean-Philippe Stephan | David Arnott | Marie Classon Guler et al. Ke Li | Feng Wang | Wen-Bin Cao | Xiao-Xi Lv | Fang Hua | Bing Cui | Jiao-Jiao Yu | Xiao-Wei Zhang | Shuang Shang | Shan-Shan Liu | Jin-Mei Yu | Ming-Zhe Han | Bo Huang | Ting-Ting Zhang | Xia Li | Jian-Dong Jiang | Zhuo-Wei Hu Li et al. show that diffuse intrinsic pontine glioma (DIPG), a fatal pediatric tumor, is vulnerable to BRD4 or CDK7 blockade, and inhibition of either synergizes with HDAC inhibition to block growth of DIPG. Fadlullah | Marcel Dreger | Karen Pickering | Joe Maltas | Garry Ashton | Ruth Mac Leod | George S. Despite historical controversy, pharmacologic ascorbate is emerging as promising cancer therapy via pro-oxidant chemistry. describe how intracellular iron pools and reactive oxygen species drive pharmacologic ascorbate’s selective toxicity to cancer cells in vitro, in mice, and in humans. show that CD276 is broadly overexpressed in cancer cells and tumor vascular cells and demonstrate anti-CD276-drug conjugates as promising anti-cancer reagents.

show that drug-tolerant persisters (DTPs), a cancer cell subpopulation surviving lethal drugs, are partly maintained by a repressed chromatin state, prominently at LINE-1 elements. define three IDH wild-type glioblastoma-intrinsic gene expression subtypes, which are partly shaped by the tumor immune environment. find that TRIB3 promotes acute promyelocytic leukemia (APL) by suppressing PML-RARα degradation and that the TRIB3 level correlates with APL progression and therapeutic resistance. Super-enhancer analysis of DIPG suggests oligodendroglial precursors as the cell of origin. Baillie | Valerie Kouskoff | Georges Lacaud | Graeme I. Messenger RNA (m RNA) modification provides an additional layer of gene regulation in cells. report that ALKBH5, a demethylase of the m RNA modification N6-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-m RNA stability and expression of the FOXM1 gene. The drug selected for conjugation is important because tumor vascular cells can be resistant to a drug to which tumor cells are sensitive.

Readings may be obtained in pounds, kilograms, or newtons. doi:10.1111/jnc.13910 Ginkgo biloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway Jatin Tulsulkar, Bryan Glueck, Terry D. Shah Translational Stroke Research, Pages, 1-12, 17 November 2015 Joint dysfunction and functional decline in middle age myostatin null mice Wen Guo, Andrew D.

These results provide a framework to improve cancer therapy by anticipating drug resistance and proposing alternative strategies. Gabrusiewicz | Guocan Wang | Eskil Eskilsson | Jian Hu | Tom Mikkelsen | Ronald A. In addition to establishing a new standard of care, these two articles pose a number of important questions for future investigation. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Syk inhibition disrupts the regulatory loop and prolongs survival of mice with Hoxa9/Meis1-driven acute myeloid leukemia. Per Hydbring | Yinan Wang | Anne Fassl | Xiaoting Li | Veronica Matia | Tobias Otto | Yoon Jong Choi | Katharine E. Nanoparticle delivery of these mi RNAs inhibits tumor growth in several xenograft models, including treatment-refractory patient-derived xenografts. Cramer-Morales | Muhammad Furqan | Sonia Sandhu | Thomas L. My first Reader story was published in 1980; I've been writing the culture column since 2000.It's been a feast of great material, including, among those in recent memory, Professor Jerry Harris's explanation of why so many of us are broke and out of work ("The Transnational Economy"); the Art Institute shuffle that bumped its Chagall windows to the back of the house ("Chagall's New Nook") ; and the state law that got artist Chris Drew in much deeper trouble than he'd bargained for when he set out to make a point about the lack of art on Chicago streets ("Accidental Poster Child"). Before that: grad student at NU, staff writer at the St.Petersburg Times, and beat reporter at City News Bureau.

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